Linked Life Data

8223742

Source:http://linkedlifedata.com/resource/pubmed/id/8223742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1993-12-17
pubmed:abstractText
Intrinsic properties of the human sinoatrial (SA) node have been shown to decline with age. In the present study we aimed at investigating the underlying mechanisms of age-dependent changes in intrinsic cycle length and sinoatrial conduction time. To this end, the cycle length and transmembrane potentials of the SA nodes of rabbits (2 days-5.6 years) and cats (6 weeks-18 years) were recorded and nodal conduction was reconstructed. The size of the SA nodes was measured in Sirius Red stained sections. Cycle length increases with age in both the rabbit and cat SA node, and in both species cycle length is dependent on diastolic depolarization rate and action potential duration. Nodal action potential duration increases with age in both rabbit and cat, whereas diastolic depolarization rate decreases in the cat only. The location of the primary pacemaker is not related to age. With age, sinoatrial conduction time increases in both species as a result of an enlargement of the area with low phase 0 upstroke velocities. The size of the SA node of adult animals does not increase with age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0195-668X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1278-88
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Electrophysiology of the ageing rabbit and cat sinoatrial node--a comparative study.
pubmed:affiliation
Department of Physiology, Academic Medical Centre, University of Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't