Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-12-15
|
| pubmed:abstractText |
The in-vitro activity of cefdinir (Cl-983, FK482), an orally absorbed aminothiazole cephalosporin, was compared with that of penicillin, ampicillin, amoxycillin, amoxycillin/clavulanic acid (2/1), cefaclor, cefuroxime, cefixime, cefotaxime, vancomycin and erythromycin against 370 clinical isolates of Gram-negative and Gram-positive bacteria. Cefdinir was highly active against Staphylococcus aureus and S. epidermidis, inhibiting 90% of the strains at doses of 0.25 and 0.5 mg/l respectively. However, cefdinir was not active against methicillin-resistant S. aureus (range 16- > 128 mg/l). The respiratory pathogens Moraxella catarrhalis, Streptococcus pneumoniae, and S. pyogenes were also susceptible (MIC90 < or = 0.5 mg/l), but against Enterococcus spp. cefdinir displayed no useful activity. The common members of the family Enterobacteriaceae were susceptible (MIC90 < or = 1 mg/l), but those possessing chromosomal beta-lactamases were more resistant (MIC90 2-8 mg/l). The presence of human serum had little effect on MICs of cefdinir. These results indicate that cefdinir exhibited a wide spectrum for an oral cephalosporin and support its possible clinical use against susceptible pathogens in infections of the skin, soft tissue, respiratory and urinary tracts.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0378-6501
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
51-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8223142-Anti-Bacterial Agents,
pubmed-meshheading:8223142-Bacteria,
pubmed-meshheading:8223142-Blood Physiological Phenomena,
pubmed-meshheading:8223142-Cephalosporins,
pubmed-meshheading:8223142-Enterobacteriaceae,
pubmed-meshheading:8223142-Gram-Negative Bacteria,
pubmed-meshheading:8223142-Gram-Positive Bacteria,
pubmed-meshheading:8223142-Humans,
pubmed-meshheading:8223142-Microbial Sensitivity Tests,
pubmed-meshheading:8223142-Moraxella (Branhamella) catarrhalis,
pubmed-meshheading:8223142-beta-Lactamases
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Cefdinir: in vitro activity study and effect of human serum.
|
| pubmed:affiliation |
Department of Microbiology, Faculty of Medicine, Hospital Clinico Universitario, Salamanca, Spain.
|
| pubmed:publicationType |
Journal Article
|