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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1993-12-22
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pubmed:abstractText |
The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of PCP occurred in eight patients; four episodes were histologically verified and four episodes were clinically assumed. The relapse rate after one year of prophylaxis was 5.1% (95% CI 0.0%-11.0%) using the log-rank test. Intolerance of secondary prophylaxis, defined as adverse effects necessitating cessation of SP with SMX-TMP, was reported in eight patients (5%) (95% CI 2.1%-9.3%).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0907-8916
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
503-5
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:8222772-AIDS-Related Opportunistic Infections,
pubmed-meshheading:8222772-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8222772-Adult,
pubmed-meshheading:8222772-Aged,
pubmed-meshheading:8222772-Dose-Response Relationship, Drug,
pubmed-meshheading:8222772-Female,
pubmed-meshheading:8222772-Follow-Up Studies,
pubmed-meshheading:8222772-Humans,
pubmed-meshheading:8222772-Male,
pubmed-meshheading:8222772-Middle Aged,
pubmed-meshheading:8222772-Pneumonia, Pneumocystis,
pubmed-meshheading:8222772-Trimethoprim-Sulfamethoxazole Combination,
pubmed-meshheading:8222772-Zidovudine
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pubmed:year |
1993
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pubmed:articleTitle |
Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.
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pubmed:affiliation |
Department of Infectious Diseases, Hvidovre Hospital, Copenhagen.
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pubmed:publicationType |
Journal Article,
Clinical Trial
|