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pubmed-article:8221988pubmed:abstractTextDesmosomes were isolated first from fresh cow nose epidermis. Desmoplakin I (DP I) was purified from desmosome preparations by SDS-polyacrylamide gel electrophoresis and anti-DP I McAb was obtained via hybridoma technique. The tissue specificity showed that all the normal epithelia, different kinds of epithelial tumors and meningioma were positive, whereas non-epithelial tissues and their corresponding tumors gave a negative result. Positive staining showed a series of punctate reaction locating along the cell-cell borders, each spot representing a desmosome or a cluster of closely spaced desmosomes. It is suggested that McAb of DP I is a reliable immunohistochemical probe for epithelial tumor and meningioma diagnosis.lld:pubmed
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pubmed-article:8221988pubmed:volume22lld:pubmed
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pubmed-article:8221988pubmed:pagination154-6lld:pubmed
pubmed-article:8221988pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8221988pubmed:year1993lld:pubmed
pubmed-article:8221988pubmed:articleTitle[Preparation, identification and preliminary application of anti-desmoplakin I monoclonal antibody].lld:pubmed
pubmed-article:8221988pubmed:affiliationDepartment of Pathology, West China University of Medical Sciences, Chengdu.lld:pubmed
pubmed-article:8221988pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8221988pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:8221988pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed