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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-12-17
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pubmed:abstractText |
Desmosomes were isolated first from fresh cow nose epidermis. Desmoplakin I (DP I) was purified from desmosome preparations by SDS-polyacrylamide gel electrophoresis and anti-DP I McAb was obtained via hybridoma technique. The tissue specificity showed that all the normal epithelia, different kinds of epithelial tumors and meningioma were positive, whereas non-epithelial tissues and their corresponding tumors gave a negative result. Positive staining showed a series of punctate reaction locating along the cell-cell borders, each spot representing a desmosome or a cluster of closely spaced desmosomes. It is suggested that McAb of DP I is a reliable immunohistochemical probe for epithelial tumor and meningioma diagnosis.
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pubmed:language |
chi
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0529-5807
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
154-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8221988-Antibodies, Monoclonal,
pubmed-meshheading:8221988-Cytoskeletal Proteins,
pubmed-meshheading:8221988-Desmoplakins,
pubmed-meshheading:8221988-Desmosomes,
pubmed-meshheading:8221988-Diagnosis, Differential,
pubmed-meshheading:8221988-Humans,
pubmed-meshheading:8221988-Hybridomas,
pubmed-meshheading:8221988-Immunohistochemistry,
pubmed-meshheading:8221988-Neoplasms
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pubmed:year |
1993
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pubmed:articleTitle |
[Preparation, identification and preliminary application of anti-desmoplakin I monoclonal antibody].
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pubmed:affiliation |
Department of Pathology, West China University of Medical Sciences, Chengdu.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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