Linked Life Data

8221160

Source:http://linkedlifedata.com/resource/pubmed/id/8221160

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-12-14
pubmed:abstractText
Mice selected for differences in nest-building behavior differ in the number of arginine-vasopressin (AVP)-immunoreactive neurons in the suprachiasmatic nuclei (SCN). Although previous efforts to link AVP-immunoreactive neurons in the SCN to clock function have failed, we show that differences in several circadian parameters are associated with differences in the number of AVP-immunoreactive neurons between the selected lines. Although an alternative interpretation is discussed, we hypothesize that these neurons may relay timing information from the circadian pacemaker in the SCN for wheel-running activity. In addition, phase-response curves (PRCs) to 15-min light pulses in constant darkness also differ between the selected lines. However, these differences are not associated with the number of the AVP-immunoreactive neurons in the SCN, but are associated with the level of nest-building behavior. Compared to the Brattleboro rat, in which homozygous rats are deficient for AVP in the entire brain, our system, exhibiting a wide range of variability, has more specific utility for studying the role of the output pathways of the SCN in circadian rhythm control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
623-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Circadian rhythms differ between selected mouse lines: a model to study the role of vasopressin neurons in the suprachiasmatic nuclei.
pubmed:affiliation
Department of Biology, Wesleyan University, Middletown, CT 06459-0170.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't