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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-10-29
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pubmed:abstractText |
Protection against group B meningococcal infection was examined using the chick embryo. 12-day-old embryos were challenged intravenously with various meningococcal strains. The chick embryo has an active reticuloendothelial system but lacks functional complement. In this model we found that protection against group B infection was primarily group specific. The group B polysaccharide antibody is an effective opsonin, but is a very poor bactericidal antibody. In contrast, the serotype antibody was bactericidal but only slightly protective in the chick embryo where protection is primarily phagocytic in nature. The group-specific and type-specific antibodies are strongly synergistic. Minute amounts of group B polysaccharide antibody caused a very significant increase in the protective effects of the serotype antibody.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-16557762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-19870925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-19870926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4121052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4134571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4189835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4197754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4206451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4629202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4631911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4632041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4632471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4964859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4977280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4977283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4979390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-4998556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-5000796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-5001751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-5028497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-804088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-805184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/822114-810522
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-29
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pubmed:dateRevised |
2010-9-3
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pubmed:meshHeading |
pubmed-meshheading:822114-Animals,
pubmed-meshheading:822114-Antibodies, Bacterial,
pubmed-meshheading:822114-Antibody Specificity,
pubmed-meshheading:822114-Chick Embryo,
pubmed-meshheading:822114-Disease Models, Animal,
pubmed-meshheading:822114-Immunization,
pubmed-meshheading:822114-Meningococcal Infections,
pubmed-meshheading:822114-Neisseria meningitidis,
pubmed-meshheading:822114-Polysaccharides, Bacterial,
pubmed-meshheading:822114-Serotyping
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pubmed:year |
1976
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pubmed:articleTitle |
Protection against group B meningococcal disease. I. Comparison of group-specific and type-specific protection in the chick embryo model.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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