Linked Life Data

8221141

Source:http://linkedlifedata.com/resource/pubmed/id/8221141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-12-7
pubmed:abstractText
Animal models of Huntington's disease (HD) and other neurological disorders have proven useful for examining the anatomical, neurochemical, and behavioral alterations in these diseases. Investigators have taken advantage of new excitotoxic models that appear to successfully simulate the neurobiological and behavioral characteristics of HD with remarkable homology. Selective excitotoxic compounds allow for a more precise and controlled lesion with which to examine the relationship between striatal damage and behavioral abnormalities. In addition, these models provide new approaches for developing and testing various treatments for HD. Fetal neural tissue transplanted into the excitotoxin-lesioned animal can integrate with the host brain and promote neurochemical and functional recovery. Neural grafting paradigms may be viewed as potential therapies for treating neurodegenerative diseases and as aids in deciphering the regenerative mechanisms of the central nervous system. Further research is necessary, however, to determine the negative and positive effects of neural transplantation. In addition, existing behavioral models need to be refined to allow for better evaluation of the subtle topographic changes in behavior resulting from fetal tissue transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Behavioral effects of fetal neural transplants: relevance to Huntington's disease.
pubmed:affiliation
Department of Surgery, University of South Florida, Tampa 33612.
pubmed:publicationType
Journal Article, Review