rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1993-12-13
|
pubmed:abstractText |
The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surgery, an upregulation of 5-HT1B receptors in the entorhinal cortex and the dorsomedial and suprachiasmatic nuclei of the hypothalamus. The cellular localization of those 5-HT1B receptors exhibiting post-lesion plastic properties is discussed.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0006-8993
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
623
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
345-8
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8221120-5,7-Dihydroxytryptamine,
pubmed-meshheading:8221120-Animals,
pubmed-meshheading:8221120-Autoradiography,
pubmed-meshheading:8221120-Axons,
pubmed-meshheading:8221120-Binding Sites,
pubmed-meshheading:8221120-Brain,
pubmed-meshheading:8221120-Denervation,
pubmed-meshheading:8221120-Hypothalamus,
pubmed-meshheading:8221120-Injections, Intraventricular,
pubmed-meshheading:8221120-Limbic System,
pubmed-meshheading:8221120-Male,
pubmed-meshheading:8221120-Rats,
pubmed-meshheading:8221120-Rats, Sprague-Dawley,
pubmed-meshheading:8221120-Receptors, Serotonin,
pubmed-meshheading:8221120-Serotonin,
pubmed-meshheading:8221120-Up-Regulation
|
pubmed:year |
1993
|
pubmed:articleTitle |
Increase of central 5-HT1B binding sites following 5,7-dihydroxytryptamine axotomy in the adult rat.
|
pubmed:affiliation |
Unité de Neuroendocrinologie Expérimentale INSERM, U 297, Marseille, France.
|
pubmed:publicationType |
Journal Article,
In Vitro
|