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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-12-9
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pubmed:abstractText |
Studies were conducted to determine whether genetic differences in behavioural effects of cocaine in C57BL/6 and DBA/2 mice might be mediated by strain differences in dopamine and serotonin transporters and dopamine D1 and D2 receptors in specific brain regions. Binding characteristics of [3H]CFT, a cocaine analogue, in the presence of either GBR12909, a dopamine uptake blocker or fluoxetine, a serotonin uptake blocker and binding of [3H]-paroxetine, a specific serotonin uptake receptor antagonist, were evaluated. We observed regional differences in [3H]CFT binding parameters in the presence of GBR12909 or fluoxetine, but no strain differences by brain region were observed. There were no differences in [3H]paroxetine binding characteristics between corresponding brain regions from C57BL and DBA/2 mice. The D1 antagonist, [3H]SCH23390 and the D2 ligands [3H]sulpiride or [125I]epidepride were used to determine dopamine receptor characteristics. Regional differences were found in [3H]SCH23390 and [3H]sulpiride, with higher affinities and lower densities in frontal cortex compared to striatum; with no differences in [3H]SCH23390 binding in corresponding tissues from C57BL and DBA/2 brains. There were strain-related differences in [3H]sulpiride and in [3H]epidepride binding in striatal membranes with higher densities in C57BL than in DBA/2. Our findings suggest striatal D2 receptor differences are possibly involved in genetic differences in cocaine-related behaviours.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/(1R-(exo,exo))-3-(4-fluorophenyl)-8-...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Paroxetine,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sulpiride,
http://linkedlifedata.com/resource/pubmed/chemical/cocaine receptor,
http://linkedlifedata.com/resource/pubmed/chemical/epidepride
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-314X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-96
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8220438-Animals,
pubmed-meshheading:8220438-Benzamides,
pubmed-meshheading:8220438-Benzazepines,
pubmed-meshheading:8220438-Binding Sites,
pubmed-meshheading:8220438-Carrier Proteins,
pubmed-meshheading:8220438-Cerebral Cortex,
pubmed-meshheading:8220438-Cocaine,
pubmed-meshheading:8220438-Corpus Striatum,
pubmed-meshheading:8220438-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:8220438-Limbic System,
pubmed-meshheading:8220438-Male,
pubmed-meshheading:8220438-Membrane Glycoproteins,
pubmed-meshheading:8220438-Membrane Transport Proteins,
pubmed-meshheading:8220438-Mice,
pubmed-meshheading:8220438-Mice, Inbred C57BL,
pubmed-meshheading:8220438-Mice, Inbred DBA,
pubmed-meshheading:8220438-Nerve Tissue Proteins,
pubmed-meshheading:8220438-Paroxetine,
pubmed-meshheading:8220438-Pharmacogenetics,
pubmed-meshheading:8220438-Pyrrolidines,
pubmed-meshheading:8220438-Receptors, Dopamine D1,
pubmed-meshheading:8220438-Receptors, Dopamine D2,
pubmed-meshheading:8220438-Receptors, Drug,
pubmed-meshheading:8220438-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:8220438-Species Specificity,
pubmed-meshheading:8220438-Sulpiride
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pubmed:year |
1993
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pubmed:articleTitle |
Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice.
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pubmed:affiliation |
Alcohol Research Center, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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