Linked Life Data

8220233

Source:http://linkedlifedata.com/resource/pubmed/id/8220233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-11-26
pubmed:abstractText
The susceptibility to lipid peroxidation induced by an iron-ascorbate system was studied in human erythrocyte membranes (ghost), and measured as thiobarbituric acid reactive substances (TBARS) formed. The male and female subjects were 13 chronic alcoholic patients aged 34-54 who assumed 200-250 g/die of ethanol, and 12 healthy controls aged 23-46. In alcoholics ghost sensitivity to lipid peroxidation was significantly decreased compared with that of the controls. Peroxidation on lipids extracted from the ghosts of both control and alcoholic subjects confirmed an increased resistance to free radical damage of the erythrocyte membranes obtained from alcoholic patients, thus indicating that in alcoholic patients the lipid component is involved in the resistance to free radical damage of erythrocyte membranes. Lipid analysis revealed no significant difference in cholesterol and phospholipid content, nor in the phospholipid classes, of the two groups considered. Nevertheless the fatty acid composition of ghosts from the alcoholic subjects was significantly lower in docosahexaenoic acid content than in the controls, and it is with this in mind we propose the explanation of the results we obtained.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1039-9712
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
807-17
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of alcohol abuse: studies on human erythrocyte susceptibility to lipid peroxidation.
pubmed:affiliation
Dipartimento di Chimica e Biochimica Medica, Facoltà di Medicina, Università degli Studi Milano, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't