| pubmed-article:8219184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0150369 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0919528 | lld:lifeskim |
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| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
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| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0011900 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:8219184 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:8219184 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8219184 | pubmed:dateCreated | 1993-12-22 | lld:pubmed |
| pubmed-article:8219184 | pubmed:abstractText | The chromosomal breakpoints of t(4;11) translocation of acute lymphoblastic leukemia (ALL) have been recently identified at molecular level and shown to involve the AF4 (FEL) gene on chromosome 4 and the ALL-1 (MLL, Hrx) gene on chromosome 11. The ALL-1/AF4 fusion gene is transcribed into a chimeric mRNA. Using primer sets derived from ALL-1 and AF4 cDNAs by reverse transcription-polymerase chain reaction (RT-PCR), we were able to amplify the breakpoint sites of the fusion transcript of all 15 ALL cases with karyotypic or molecular evidence of the t(4;11). DNA fragments of different size were obtained as the consequence of different breakpoints on chromosome 11 and the presence of alternative splicing of ALL-1 exon 8. The feasibility of monitoring the residual cells carrying the t(4;11) in 2 ALL patients with different clinical outcome was evaluated. Overall, the presented results provide evidence that RT-PCR can be used as a rapid method for detecting this chromosomal abnormality and following the patient's response to therapy. | lld:pubmed |
| pubmed-article:8219184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8219184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8219184 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8219184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8219184 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8219184 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:MandelliFF | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:RossoHH | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:BarbuiTT | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:BattistaRR | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:BassoGG | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:MaseraGG | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:ChaeE UEU | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:BiondiAA | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:RambaldiAA | lld:pubmed |
| pubmed-article:8219184 | pubmed:author | pubmed-author:CasliniCC | lld:pubmed |
| pubmed-article:8219184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8219184 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8219184 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:8219184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8219184 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8219184 | pubmed:pagination | 2943-7 | lld:pubmed |
| pubmed-article:8219184 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8219184 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8219184 | pubmed:articleTitle | Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation. | lld:pubmed |
| pubmed-article:8219184 | pubmed:affiliation | Clinical Pediatrica Università di Milano, Ospedale San Gerardo, Monza, Italy. | lld:pubmed |
| pubmed-article:8219184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8219184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4297 | entrezgene:pubmed | pubmed-article:8219184 | lld:entrezgene |
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