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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1993-12-22
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pubmed:abstractText |
Greyhounds (n = 38) were randomized to aspirin and dipyridamole (ASA + DPM), the thromboxane synthetase inhibitor (TSI) CGS12970 (CIBA-GEIGY) or placebo twice daily for 48 hours prior to bilateral implantation of femoral artery Dacron grafts. In-vivo 111In-platelet deposition on grafts was measured at 5 days and 2 months. Grafts were removed at 2 months when ex-vivo graft and arterial release of 6-ketoprostaglandin F1a (6-keto PGF1a) was measured by radioimmunoassay. Graft 6-keto-PGF1a was significantly increased by CGS12970 but ASA + DPM had no significant effect. ASA + DPM significantly reduced arterial 6-keto-PGF1a although this was marginally increased by CGS12970. Neither active treatment reduced in-vivo 111In-platelet deposition. Preservation of vascular or graft prostacyclin by thromboxane synthetase inhibitors may represent an alternative strategy in preventing prosthetic graft thrombosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0959-9673
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8217777-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:8217777-Animals,
pubmed-meshheading:8217777-Aspirin,
pubmed-meshheading:8217777-Blood Vessel Prosthesis,
pubmed-meshheading:8217777-Dipyridamole,
pubmed-meshheading:8217777-Dogs,
pubmed-meshheading:8217777-Drug Therapy, Combination,
pubmed-meshheading:8217777-Female,
pubmed-meshheading:8217777-Femoral Artery,
pubmed-meshheading:8217777-Graft Occlusion, Vascular,
pubmed-meshheading:8217777-Pyridines,
pubmed-meshheading:8217777-Random Allocation,
pubmed-meshheading:8217777-Thromboxane-A Synthase
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pubmed:year |
1993
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pubmed:articleTitle |
The effect of platelet inhibitory therapy on graft thromboresistance.
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pubmed:affiliation |
Bloomsbury Vascular Unit, Middlesex Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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