Linked Life Data

821729

Source:http://linkedlifedata.com/resource/pubmed/id/821729

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1976-10-20
pubmed:abstractText
Thienylcarbenicillin is another semisynthetic penicillin with a wide range of antibacterial activity including most of gram-negative bacterias, even such as Pseudomonas aeruginosa. To investigate penetration activities into bone and another tissues, 120 specimens of serum and 120 specimens of tissue were obtained from 20 patients, after i.v. injection of a single doses of 150 mg thienylcarbenicillin per kg body weight. The evaluation of concentration showed that Thienylcarbenicillin was eliminated from serum in a half-life time of 77 minutes. The concentration varied in different tissues. Maximal levels were found in musculature and in spongy bone. Unexpected high concentrations were found in fascia and in cutis. The lowest concentration was found in subcutis and compact bone. The experimental doses of 150 mg/kg body weight was not enough to gain a sufficient therapeutical level in compact bone.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-4722
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[Studies on the distribution of thienylcarbenicillin in the human tissue].
pubmed:publicationType
Journal Article, English Abstract