| pubmed-article:8217053 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0002575 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0031412 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0031507 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0009951 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0080356 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0205289 | lld:lifeskim |
| pubmed-article:8217053 | lifeskim:mentions | umls-concept:C0050010 | lld:lifeskim |
| pubmed-article:8217053 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8217053 | pubmed:dateCreated | 1993-12-6 | lld:pubmed |
| pubmed-article:8217053 | pubmed:abstractText | Aminophylline (theophylline2.ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous theophylline/kg). In contrast, 8-(p-sulfophenyl)theophylline (a theophylline derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine. | lld:pubmed |
| pubmed-article:8217053 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8217053 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217053 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8217053 | pubmed:issn | 0300-9564 | lld:pubmed |
| pubmed-article:8217053 | pubmed:author | pubmed-author:KleinrokZZ | lld:pubmed |
| pubmed-article:8217053 | pubmed:author | pubmed-author:CzuczwarS JSJ | lld:pubmed |
| pubmed-article:8217053 | pubmed:author | pubmed-author:KozickaMM | lld:pubmed |
| pubmed-article:8217053 | pubmed:author | pubmed-author:BorowiczKK | lld:pubmed |
| pubmed-article:8217053 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8217053 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8217053 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8217053 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8217053 | pubmed:pagination | 157-63 | lld:pubmed |
| pubmed-article:8217053 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:meshHeading | pubmed-meshheading:8217053-... | lld:pubmed |
| pubmed-article:8217053 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8217053 | pubmed:articleTitle | Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice. | lld:pubmed |
| pubmed-article:8217053 | pubmed:affiliation | Department of Pharmacology, Lublin Medical School, Poland. | lld:pubmed |
| pubmed-article:8217053 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8217053 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
