Linked Life Data

8215832

Source:http://linkedlifedata.com/resource/pubmed/id/8215832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1993-11-2
pubmed:abstractText
We report a case of a clival chordoma in a 21-year-old man that ultrastructurally demonstrated large numbers of microtubule aggregates within the rough endoplasmic reticulum. Histologically, the tumor demonstrated classic chordoma architecture characterized by numerous physaliphorous cells and an abundant extracellular matrix. The tumor cells stained strongly for cytokeratin, S100 protein, and epithelial membrane antigen, indicative of the epithelial origin of this tumor. Ultrastructurally, the most conspicuous feature of this tumor consisted of parallel bundles of criss-crossing microtubules within the rough endoplasmic reticulum. These microtubules had a diameter of approximately 27 nm and did not demonstrate an internal structure. To our knowledge, this is the first report of microtubule aggregates in a spheno-occipital chordoma. We note that microtubule aggregates have been described in a number of different entities, and though proposed as a specific feature of "chondroid chordoma," they are a nonspecific finding.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-9985
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1055-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Microtubule aggregates in a clival chordoma.
pubmed:affiliation
Department of Pathology, University of California, San Francisco.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Case Reports