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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
8
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|
pubmed:dateCreated |
1993-11-5
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|
pubmed:abstractText |
The postantibiotic effect (PAE) following three consecutive 2-h exposures to imipenem, temafloxacin, and tobramycin was determined in Pseudomonas aeruginosa. A PAE and a bactericidal effect were consistently observed for imipenem following each cycle of drug exposure and regrowth. In contrast, the PAE increased with repeated exposure with temafloxacin (1.8 to > 5 h), but disappeared with tobramycin by the third exposure (0.9 to 0 h). These data show that the in vitro PAE may change within a strain following multiple cycles of drug exposure and bacterial regrowth.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0066-4804
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
37
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1723-5
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|
pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
|
pubmed:year |
1993
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|
pubmed:articleTitle |
In vitro postantibiotic effect following repeated exposure to imipenem, temafloxacin, and tobramycin.
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|
pubmed:affiliation |
Antiinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy, Roger Williams Medical Center, Providence 02908.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
