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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3 Pt 2
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pubmed:dateCreated |
1993-11-22
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pubmed:abstractText |
We examined the effect of dietary polyunsaturated fatty acids (PUFA) on cardiac sympathetic neurotransmission. Rats were fed semisynthetic diets (18.5% fat wt/wt) high in saturated fatty acids (control diet), high in n-6 PUFA (corn oil), or enriched with n-3 PUFA (Maxepa). A perfused innervated heart model was used to examine different aspects of sympathetic neurotransmission 10 wk after the feeding. Dietary PUFA increased the content of n-6 or n-3 PUFA in myocardial phospholipids compared with animals fed control diets. Myocardial norepinephrine content, sympathetic nerve stimulation-induced norepinephrine release, neural reuptake, presynaptic alpha-adrenergic inhibition of norepinephrine release, and postsynaptic inotropic response (+/- dP/dt) to sympathetic nerve stimulation or to a beta-agonist were essentially not influenced by dietary PUFA. Neural norepinephrine release during prolonged ischemia (60 min) was also similar in hearts from rats fed n-6 PUFA and control diets. Thus a modification of sympathetic neurotransmission was not achieved by feeding PUFA-enriched diets for 10 wk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9513
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
265
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H886-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8214123-Animals,
pubmed-meshheading:8214123-Dietary Fats,
pubmed-meshheading:8214123-Electric Stimulation,
pubmed-meshheading:8214123-Fats, Unsaturated,
pubmed-meshheading:8214123-Fatty Acids,
pubmed-meshheading:8214123-Fatty Acids, Omega-6,
pubmed-meshheading:8214123-Fatty Acids, Unsaturated,
pubmed-meshheading:8214123-Heart Conduction System,
pubmed-meshheading:8214123-Isoproterenol,
pubmed-meshheading:8214123-Male,
pubmed-meshheading:8214123-Myocardial Contraction,
pubmed-meshheading:8214123-Myocardial Ischemia,
pubmed-meshheading:8214123-Myocardium,
pubmed-meshheading:8214123-Norepinephrine,
pubmed-meshheading:8214123-Rats,
pubmed-meshheading:8214123-Rats, Inbred Lew,
pubmed-meshheading:8214123-Sympathetic Nervous System,
pubmed-meshheading:8214123-Synaptic Transmission
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pubmed:year |
1993
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pubmed:articleTitle |
Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts.
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pubmed:affiliation |
Department of Medicine (Royal Infirmary of Edinburgh), University of Edinburgh, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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