Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-10-28
pubmed:abstractText
Regressive logistic models specify the probability distribution of familial binary traits by conditioning each individual's phenotype on those of preceding relatives; therefore, the expression of the joint probability of the familial data necessitates ordering the observations. In the present paper, we propose an autologistic model of this familial dependence structure, which does not require specification of a particular ordering of the phenotypic observations. Genetic effects are introduced into the model in order to perform segregation analysis that is aimed at detecting the role of a major locus in the expression of familial phenotypes. In this model, the conditional probabilities have a logistic form, and large patterns of dependence between relatives can be considered with a simple interpretation of the parameters measuring the relationship between two phenotypes. The model is compared with the regressive logistic approach in terms of odds ratios and by using a simulation study.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1415253, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1487139, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1555847, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1786318, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1792461, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1823088, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-1897524, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-2292365, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-2591730, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-3233244, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-3567294, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-373427, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-4842773, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-5149961, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-7228062, http://linkedlifedata.com/resource/pubmed/commentcorrection/8213818-727713
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
894-907
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
An autologistic model for the genetic analysis of familial binary data.
pubmed:affiliation
INSERM Unité 194, Service de Biostatistiques et d'Informatique Médicale, Hôpital Pitié-Salpétrière, Paris, France.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't