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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-11-19
|
| pubmed:abstractText |
One hundred forty-five patients on regular hemodialysis (HD) at our institution were evaluated for the presence of hepatitis C virus (HCV) infection. Forty-three patients (29%) were found to have detectable antibodies to HCV using second-generation enzyme-linked immunosorbent and recombinant immunoblot assays. Forty positive patients (anti-HCV+) and 10 negative patients (anti-HCV-) were tested for direct detection of the HCV genome by the polymerase chain reaction (PCR). Twenty-one anti-HCV+ patients (52%) had detectable RNA HCV in plasma (PCR+). No anti-HCV- patient had viremia. In addition, we compared the 43 anti-HCV+ patients with the 102 anti-HCV- patients for duration of HD, history of blood transfusion, serologic markers of hepatitis B virus, and acute and chronic liver disease. On retrospective univariate analysis, statistically significant associations with anti-HCV+ were duration of HD (P = 0.0001), blood transfusions (P = 0.0005), co-infection with hepatitis B virus (P = 0.01), and acute and chronic liver disease (P = 0.06 and 0.01, respectively). Three significant variables (duration of HD, chronic hepatitis, and blood transfusions) of the multivariate analysis permit the classification of 65% of anti-HCV+ patients and 81% of anti-HCV- patients. In the anti-HCV+ group, when the same parameters were compared in PCR+ or PCR- patients, no statistical difference appeared. These results reveal that 52% of anti-HCV+ HD patients have HCV infection. The clinical consequences of HCV infection in that population are not characterized since no difference has been documented between PCR+ and PCR- results.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0272-6386
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
574-80
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8213798-Adolescent,
pubmed-meshheading:8213798-Adult,
pubmed-meshheading:8213798-Aged,
pubmed-meshheading:8213798-Aged, 80 and over,
pubmed-meshheading:8213798-Base Sequence,
pubmed-meshheading:8213798-Discriminant Analysis,
pubmed-meshheading:8213798-Female,
pubmed-meshheading:8213798-Hepacivirus,
pubmed-meshheading:8213798-Hepatitis C,
pubmed-meshheading:8213798-Humans,
pubmed-meshheading:8213798-Kidney Failure, Chronic,
pubmed-meshheading:8213798-Male,
pubmed-meshheading:8213798-Middle Aged,
pubmed-meshheading:8213798-Molecular Sequence Data,
pubmed-meshheading:8213798-Polymerase Chain Reaction,
pubmed-meshheading:8213798-Prevalence,
pubmed-meshheading:8213798-RNA, Viral,
pubmed-meshheading:8213798-Renal Dialysis
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Detection of hepatitis C infection by polymerase chain reaction among hemodialysis patients.
|
| pubmed:affiliation |
Service de Néphrologie et d'Hémodialyse, Hôpital Sainte-Marguerite, Marseille, France.
|
| pubmed:publicationType |
Journal Article
|