Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
1993-11-5
|
| pubmed:abstractText |
Non-steroidal anti-inflammatory drugs obviously act also on the central nervous system. We, therefore, studied the effect of diclofenac 3 mg/kg and ketoprofen 4 mg/kg on the minimum alveolar concentration (MAC) of halothane in 10 New Zealand White rabbits. After determination of halothane MAC, total doses of NSAIDs were administered intravenously as three subdoses: 12.5%, 37.5% and 50% of the total dose. Depth of anaesthesia did not increase significantly after the first two doses with either drug. With ketoprofen, halothane MAC increased after subdose 3 from 1.52 (SD 0.42) vol% to 1.9 (SD 0.36) vol% (p < 0.01). With diclofenac, halothane MAC increased after subdose 3 from 1.44 (SD 0.18) vol% to 1.60 (SD 0.39) vol% (ns). With both drugs, large interindividual differences of MAC appeared after full doses of NSAIDs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0065-4299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
286-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8213356-Anesthesia, Inhalation,
pubmed-meshheading:8213356-Animals,
pubmed-meshheading:8213356-Diclofenac,
pubmed-meshheading:8213356-Female,
pubmed-meshheading:8213356-Halothane,
pubmed-meshheading:8213356-Injections, Intravenous,
pubmed-meshheading:8213356-Ketoprofen,
pubmed-meshheading:8213356-Rabbits,
pubmed-meshheading:8213356-Random Allocation
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
The effect of diclofenac and ketoprofen on halothane MAC in rabbit.
|
| pubmed:affiliation |
Department of Anaesthesiology, Tampere University Hospital, Finland.
|
| pubmed:publicationType |
Journal Article
|