Linked Life Data

8213186

Source:http://linkedlifedata.com/resource/pubmed/id/8213186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-10-22
pubmed:abstractText
The rostral ventrolateral medulla (rVLM) is known to play an important role in cardiorespiratory control. In the rVLM an 'apnoea region', in which unilateral focal blocks induce strong depressant effects on inspiratory activity up to complete apnoea, has been described. This study was designed to systematically investigate the effects provoked by unilateral micro-injections (10-30 nl) of D,L-homocysteic acid 160 mM into this region on respiratory activity and arterial blood pressure in pentobarbitone anaesthetized, vagotomized, paralyzed and artificially ventilated cats. Micro-injections into the rostral portion of this area caused depressant respiratory responses up to complete apnoea, while micro-injections into more caudally located sites induced excitatory respiratory responses. Similar effects were observed in the activity of phrenic nerves and inspiration-related medullary neurons of both the dorsal and ventral respiratory group. The respiratory responses could be accompanied by marked increases in blood pressure (> or = 30 mmHg), especially at locations ventral to the retrofacial and facial nucleus; however, they could also occur in the absence of appreciable changes or even in association with slight decreases in blood pressure. Similar respiratory and pressor effects were observed in carotid sinus denervated cats. The results indicate that two distinct rVLM neuronal populations, one located more rostrally and the other more caudally, may have an important role in the genesis and/or maintenance of respiratory rhythm by exerting respectively inhibitory and excitatory influences on inspiratory activity. Furthermore, they support the hypothesis that different neural substrates of the rVLM are involved in the regulation of respiratory and cardiovascular functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Excitatory and depressant respiratory responses to chemical stimulation of the rostral ventrolateral medulla in the cat.
pubmed:affiliation
Dipartimento di Scienze Fisiologiche, Università di Firenze, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't