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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1993-10-26
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pubmed:abstractText |
Successful field oral vaccination and protection against viral diseases have so far been achieved only with live-attenuated or live-recombinant virus vaccines. In this communication, we present data that demonstrate that a glycoprotein derived from recombinant baculovirus-infected insect cells is efficacious as an oral vaccine. The glycoprotein (G) of rabies virus (Evelyn Rokitnicki Abelseth strain) was abundantly expressed in a baculovirus expression system and oral vaccination of racoons with the baculovirus-expressed G protein resulted in the production of rabies virus-neutralizing antibodies and protection against a lethal challenge with a street rabies virus. The potential for using the baculovirus-expressed G protein for oral immunization of wildlife is discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rabies Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein G, Rabies virus
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pubmed:status |
MEDLINE
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
925-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8212838-Administration, Oral,
pubmed-meshheading:8212838-Animals,
pubmed-meshheading:8212838-Antibodies, Viral,
pubmed-meshheading:8212838-Antigens, Viral,
pubmed-meshheading:8212838-Baculoviridae,
pubmed-meshheading:8212838-Cells, Cultured,
pubmed-meshheading:8212838-Cricetinae,
pubmed-meshheading:8212838-Glycoproteins,
pubmed-meshheading:8212838-Kidney,
pubmed-meshheading:8212838-Mesocricetus,
pubmed-meshheading:8212838-Moths,
pubmed-meshheading:8212838-Rabies,
pubmed-meshheading:8212838-Rabies Vaccines,
pubmed-meshheading:8212838-Rabies virus,
pubmed-meshheading:8212838-Raccoons,
pubmed-meshheading:8212838-Recombinant Fusion Proteins,
pubmed-meshheading:8212838-Vaccination,
pubmed-meshheading:8212838-Vaccines, Synthetic,
pubmed-meshheading:8212838-Viral Envelope Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Oral vaccination of racoons (Procyon lotor) with baculovirus-expressed rabies virus glycoprotein.
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pubmed:affiliation |
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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