Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-7-14
|
| pubmed:abstractText |
We studied the efficacy and safety of intravenous ondansetron 4 mg for the prevention of postoperative nausea and vomiting after minor gynaecological laparoscopic surgery in Oriental women. This double-blind randomised study compared ondansetron with placebo, given before the induction of anaesthesia. The anaesthetic technique used thiopentone, fentanyl, atracurium, nitrous oxide and isoflurane. Patients were studied for 24 h with nausea assessed using a verbal numeric scale from 0-10 and emetic episodes recorded as they occurred. Results were available for 102 patients in each group. In the first postoperative hour, fewer patients in the ondansetron Group (12%) had emetic episodes compared with the placebo group (33%, P < 0.01). Nausea score over the first hour (sum of three readings at 0, 30 and 60 min) was lower in the ondansetron group (median 1.6) compared with the placebo group (3.1, P < 0.05). Over the 24 h period, fewer patients in the ondansetron group had emetic episodes (25%) or nausea (43%) compared with patients in the placebo group (56%, P < 0.01) and (58%, P < 0.05) respectively. No adverse events were seen. Ondansetron 4 mg was more effective than placebo in preventing postoperative nausea and vomiting throughout the 24 h after minor laparoscopic surgery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0310-057X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
142-6
|
| pubmed:dateRevised |
2006-8-28
|
| pubmed:meshHeading |
pubmed-meshheading:8210015-Adult,
pubmed-meshheading:8210015-Anesthesia, Inhalation,
pubmed-meshheading:8210015-Anesthesia, Intravenous,
pubmed-meshheading:8210015-Double-Blind Method,
pubmed-meshheading:8210015-Female,
pubmed-meshheading:8210015-Follow-Up Studies,
pubmed-meshheading:8210015-Genitalia, Female,
pubmed-meshheading:8210015-Humans,
pubmed-meshheading:8210015-Laparoscopy,
pubmed-meshheading:8210015-Meperidine,
pubmed-meshheading:8210015-Motion Sickness,
pubmed-meshheading:8210015-Nausea,
pubmed-meshheading:8210015-Ondansetron,
pubmed-meshheading:8210015-Placebos,
pubmed-meshheading:8210015-Premedication,
pubmed-meshheading:8210015-Prochlorperazine,
pubmed-meshheading:8210015-Sterilization, Reproductive,
pubmed-meshheading:8210015-Time Factors,
pubmed-meshheading:8210015-Vomiting
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Ondansetron 4 mg for the prevention of nausea and vomiting after minor laparoscopic gynaecological surgery.
|
| pubmed:affiliation |
Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|