Linked Life Data

8208773

Source:http://linkedlifedata.com/resource/pubmed/id/8208773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-7-11
pubmed:abstractText
When administered under a backward conditioning paradigm, 5-HTP administration resulted in a decrease in ethanol intake followed by a persistently decreased ethanol consumption. A central component to this inhibitory effect was suggested by the inability of xylamidine to significantly reduce the initial inhibitory effect of 5-HTP. The persistent rejection was prevented by xylamidine. Methysergide reduced the initial as well as the persistent effects of 5-HTP. In studies utilizing a forward conditioning paradigm, 5-HTP and lithium were each effective in developing CTAs to ethanol and saccharin. Only the ethanol-5-HTP pairing showed a persistent aversion. A peripheral component to the actions of 5-HTP was suggested by xylamidine blocking the CTAs induced by 5-HTP. Xylamidine also prevented the persistent ethanol avoidance induced by 5-HTP, but was ineffective in antagonizing lithium-induced CTAs. These results suggest central as well as peripheral components associated with the inhibitory effects of 5-HTP on ethanol consumption. Central actions appear to mediate the initial inhibitory effects while peripheral actions appear to be associated with persistent avoidance of ethanol following 5-HTP treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Central and peripheral components of the inhibitory actions of 5-HTP on ethanol consumption in the rat.
pubmed:affiliation
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't