Linked Life Data

8207981

Source:http://linkedlifedata.com/resource/pubmed/id/8207981

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-7-13
pubmed:abstractText
In summary, we propose that the haemopoietic system consists of a hierarchy of clonogenic stem and progenitor cells and that the stochastic effect is superimposed upon these compartments. This means that (i) considerable heterogeneity can exist within major compartments without the need to invoke the existence of numerous subpopulations, and (ii) that the stochastic effect and the separation of stem cells are not totally incompatible. The unifying model offers a reasonable explanation of the situations summarized above. The clear implication of the disappearance of stem cell clones as a result of the stochastic effect is a requirement for multiple stem cells to ensure long-term repopulation in cell replacement or gene therapy. The necessary multiplicity may not be great, possibly 3-fold according to the results of Lemishka, and the scheme shown in Figure 1, but should be considered in the design and interpretation of experimental and therapeutic strategies. Other implications are concerned with the degree to which it is necessary to select 'subpopulations' of haemopoietic stem cells for transplantation or experimental work.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1068-72; discussion 1072-3
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Routes to repopulation--a unification of the stochastic model and separation of stem-cell subpopulations.
pubmed:affiliation
Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't