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pubmed-article:8207841pubmed:abstractTextA human immunodeficiency virus type 1 mutant with a single amino acid change (designated 596 W/M) in the ectodomain of the gp41 transmembrane envelope glycoprotein replicated in T-cell lines and in CD4-positive peripheral blood mononuclear cells identically to the wild-type virus. However, the cytopathic effects associated with infection by the mutant virus were altered, with a marked attenuation of syncytium formation and a significant delay in single-cell lysis relative to those of the wild-type virus-infected culture. The 596 W/M mutant is apparently defective in a function that is dispensable for virus entry but that contributes to the efficiency of induction of viral cytopathic effects.lld:pubmed
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pubmed-article:8207841pubmed:articleTitleChanges in the cytopathic effects of human immunodeficiency virus type 1 associated with a single amino acid alteration in the ectodomain of the gp41 transmembrane glycoprotein.lld:pubmed
pubmed-article:8207841pubmed:affiliationDana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.lld:pubmed
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pubmed-article:8207841pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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