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rdf:type |
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lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0019704,
umls-concept:C0205171,
umls-concept:C0332281,
umls-concept:C0333467,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0913822,
umls-concept:C0913823,
umls-concept:C1415205,
umls-concept:C1515926
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pubmed:issue |
7
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pubmed:dateCreated |
1994-7-13
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pubmed:abstractText |
A human immunodeficiency virus type 1 mutant with a single amino acid change (designated 596 W/M) in the ectodomain of the gp41 transmembrane envelope glycoprotein replicated in T-cell lines and in CD4-positive peripheral blood mononuclear cells identically to the wild-type virus. However, the cytopathic effects associated with infection by the mutant virus were altered, with a marked attenuation of syncytium formation and a significant delay in single-cell lysis relative to those of the wild-type virus-infected culture. The 596 W/M mutant is apparently defective in a function that is dispensable for virus entry but that contributes to the efficiency of induction of viral cytopathic effects.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1283526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1501286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1527842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1548744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1548769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1702159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1714520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1717715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1727497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1727607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1768461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1870209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-1985197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2002555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2191297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2243396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2325207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2428879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2511447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2586564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2665081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2771954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2832945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2957508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2984774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2986290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-2994223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-3001934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-3016552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-3094962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-3095663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-3496970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-3629244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-6083454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-6096719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-6189183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-6200936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-6318629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-8095306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-8369163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8207841-8474172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4662-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8207841-Antigens, CD4,
pubmed-meshheading:8207841-Cells, Cultured,
pubmed-meshheading:8207841-Cytopathogenic Effect, Viral,
pubmed-meshheading:8207841-HIV Envelope Protein gp41,
pubmed-meshheading:8207841-HIV-1,
pubmed-meshheading:8207841-Humans,
pubmed-meshheading:8207841-Mutagenesis, Site-Directed
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pubmed:year |
1994
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pubmed:articleTitle |
Changes in the cytopathic effects of human immunodeficiency virus type 1 associated with a single amino acid alteration in the ectodomain of the gp41 transmembrane glycoprotein.
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pubmed:affiliation |
Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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