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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-7-11
|
| pubmed:abstractText |
The degradation kinetics of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone 4-imine (1) in a 25% solution of ethyl alcohol in water has been studied. The rate constants were observed to follow pseudo-first-order kinetics in all cases. The pH-rate profile indicated a negligible decomposition at pH values higher than its pKa2 value [5.4 +/- 0.14 (*n = 6)]. Un-ionized 1 was subject to specific acid catalysis. The ionic strength did not affect the stability of the drug. These data can be used to develop a stable oral liquid dosage form of the drug.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-3549
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
336-8
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:8207677-Drug Stability,
pubmed-meshheading:8207677-Hydrogen-Ion Concentration,
pubmed-meshheading:8207677-Isoxazoles,
pubmed-meshheading:8207677-Naphthoquinones,
pubmed-meshheading:8207677-Spectrophotometry, Ultraviolet,
pubmed-meshheading:8207677-Temperature,
pubmed-meshheading:8207677-Trypanocidal Agents
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Isoxazoles. 8. Preformulation studies of an isoxazolylnaphthoquinone derivative.
|
| pubmed:affiliation |
Departmento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Argentina.
|
| pubmed:publicationType |
Journal Article
|