| pubmed-article:8206858 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8206858 | lifeskim:mentions | umls-concept:C0023238 | lld:lifeskim |
| pubmed-article:8206858 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:8206858 | lifeskim:mentions | umls-concept:C0022091 | lld:lifeskim |
| pubmed-article:8206858 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8206858 | pubmed:dateCreated | 1994-7-14 | lld:pubmed |
| pubmed-article:8206858 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8206858 | pubmed:abstractText | Legionella pneumophila, the causative agent of Legionnaires' disease, contains two superoxide dismutases (SODs), a cytoplasmic iron enzyme (FeSOD) and a periplasmic copper-zinc SOD. To study the role of the FeSOD in L. pneumophila, the cloned FeSOD gene (sodB) was inactivated with Tn903dIIlacZ, forming a sodB::lacZ gene fusion. By using this fusion, expression of sodB was shown to be unaffected by a variety of conditions, including several that influence sod expression in Escherichia coli: aeration, oxidants, the redox cycling compound paraquat, manipulation of iron levels in the medium, and the stage of growth. A reproducible twofold decrease in sodB expression was found during growth on agar medium containing charcoal, a potential scavenger of oxyradicals, in comparison with growth on the same medium without charcoal. No induction was seen during growth in human macrophages. Additional copies of sodB+ in trans increased resistance to paraquat. Construction of a sodB mutant was attempted by allelic exchange of the sodB::lacZ fusion with the chromosomal copy of sodB. The mutant could not be isolated, and the allelic exchange was possible only if wild-type sodB was present in trans. These results indicate that the periplasmic copper-zinc SOD cannot replace the FeSOD. The data strongly suggest that sodB is an essential gene and that FeSOD is required for the viability of L. pneumophila. In contrast, Sod- mutants of E. coli and Streptococcus mutans grow aerobically and SOD is not required for viability in these species. | lld:pubmed |
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| pubmed-article:8206858 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8206858 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8206858 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8206858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8206858 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8206858 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8206858 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:8206858 | pubmed:author | pubmed-author:WilsonJ WJW | lld:pubmed |
| pubmed-article:8206858 | pubmed:author | pubmed-author:ShumanH AHA | lld:pubmed |
| pubmed-article:8206858 | pubmed:author | pubmed-author:SteinmanH MHM | lld:pubmed |
| pubmed-article:8206858 | pubmed:author | pubmed-author:SadoskyA BAB | lld:pubmed |
| pubmed-article:8206858 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8206858 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:8206858 | pubmed:geneSymbol | sodB | lld:pubmed |
| pubmed-article:8206858 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8206858 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8206858 | pubmed:pagination | 3790-9 | lld:pubmed |
| pubmed-article:8206858 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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