| pubmed-article:8206511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C1706701 | lld:lifeskim |
| pubmed-article:8206511 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8206511 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8206511 | pubmed:dateCreated | 1994-7-11 | lld:pubmed |
| pubmed-article:8206511 | pubmed:abstractText | The mechanism whereby small resting (high buoyant density) murine B cells are induced to express interleukin-2 receptors (IL-2R) and to respond to IL-2 was addressed by staining with anti-IL-2R alpha and -IL-2R beta monoclonal antibodies (mAb), and using receptor-specific cDNA probes. Resting B cells expressed undetectable levels of both IL-2R alpha and beta chains on their surface and did not respond to IL-2, even at supra-physiological concentrations. Sepharose-coupled, but not streptavidin-cross-linked, plastic-adsorbed or soluble, anti-mu up-regulated the expression of IL-2R alpha and beta chains and mRNA to levels comparable to those seen in activated T cells. Anti-mu-stimulated B cells responded to IL-2 by incorporation of [3H]thymidine and high rate immunoglobulin (Ig) secretion. Both IL-5 (at optimal concentration) and suboptimal lipopolysaccharide (LPS; 20 ng/ml) induced surface expression of IL-2R alpha. The level of expression induced by IL-5 was equivalent to that on anti-Ig-activated B cells. Neither stimulus induced detectable expression of IL-2R beta, and neither induced B cells to respond to IL-2. IL-2R alpha expression was strongly enhanced, and low levels of IL-2R beta staining and mRNA were induced by the combination of LPS plus IL-5. LPS+IL-5-treated B cells responded to IL-2 by Ig secretion. This indicates that B cells regulate their responsiveness to IL-2 similarly to T cells, via the combined level of expression of IL-2R beta and IL-2R alpha. The synergy between IL-5 and LPS for B-cell responses shows a requirement for complementary stimuli such as would be provided by cytokines, and either cellular interaction or antigen recognition in regulation of B-cell responsiveness to IL-2. | lld:pubmed |
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| pubmed-article:8206511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8206511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8206511 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8206511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8206511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8206511 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8206511 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8206511 | pubmed:author | pubmed-author:OwensTT | lld:pubmed |
| pubmed-article:8206511 | pubmed:author | pubmed-author:PoudrierJJ | lld:pubmed |
| pubmed-article:8206511 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8206511 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:8206511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8206511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8206511 | pubmed:pagination | 373-80 | lld:pubmed |
| pubmed-article:8206511 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8206511 | pubmed:meshHeading | pubmed-meshheading:8206511-... | lld:pubmed |
| pubmed-article:8206511 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8206511 | pubmed:articleTitle | The acquisition of cytokine responsiveness by murine B cells: a role for antigen and IL-5 in the induction of IL-2 receptors. | lld:pubmed |
| pubmed-article:8206511 | pubmed:affiliation | Department of Medicine, McGill University, Montreal, Quebec, Canada. | lld:pubmed |
| pubmed-article:8206511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8206511 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8206511 | lld:pubmed |
