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pubmed-article:8206400pubmed:abstractTextTwelve patients with recurrent squamous cell carcinoma of the cervix restricted to the pelvis were treated with intra-arterial infusion of carboplatin. The initial carboplatin dose was 300 mg/m2, every 4 weeks, and the dose was escalated to 450 mg/m2. Myelosuppression was the dose-limiting toxicity at the 450 mg/m2 dose. One patient died of treatment-related febrile neutropenia at that dose level. Two patients having received one cycle at 300 mg/m2 suffered grade 3 peripheral paresthesia. There were no objective responses but five patients had a subjective improvement of pain and performance status.lld:pubmed
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pubmed-article:8206400pubmed:articleTitleA pilot study of intra-arterial carboplatin in patients with recurrent carcinoma of the cervix, postradiation.lld:pubmed
pubmed-article:8206400pubmed:affiliationOttawa Regional Cancer Centre, Ontario, Canada.lld:pubmed
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