rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1994-7-14
|
pubmed:abstractText |
Twelve patients with recurrent squamous cell carcinoma of the cervix restricted to the pelvis were treated with intra-arterial infusion of carboplatin. The initial carboplatin dose was 300 mg/m2, every 4 weeks, and the dose was escalated to 450 mg/m2. Myelosuppression was the dose-limiting toxicity at the 450 mg/m2 dose. One patient died of treatment-related febrile neutropenia at that dose level. Two patients having received one cycle at 300 mg/m2 suffered grade 3 peripheral paresthesia. There were no objective responses but five patients had a subjective improvement of pain and performance status.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0090-8258
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
53
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
290-3
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8206400-Adult,
pubmed-meshheading:8206400-Aged,
pubmed-meshheading:8206400-Aged, 80 and over,
pubmed-meshheading:8206400-Carboplatin,
pubmed-meshheading:8206400-Carcinoma, Squamous Cell,
pubmed-meshheading:8206400-Chemotherapy, Adjuvant,
pubmed-meshheading:8206400-Combined Modality Therapy,
pubmed-meshheading:8206400-Feasibility Studies,
pubmed-meshheading:8206400-Female,
pubmed-meshheading:8206400-Humans,
pubmed-meshheading:8206400-Infusions, Intra-Arterial,
pubmed-meshheading:8206400-Male,
pubmed-meshheading:8206400-Middle Aged,
pubmed-meshheading:8206400-Neoplasm Recurrence, Local,
pubmed-meshheading:8206400-Pilot Projects,
pubmed-meshheading:8206400-Uterine Cervical Neoplasms
|
pubmed:year |
1994
|
pubmed:articleTitle |
A pilot study of intra-arterial carboplatin in patients with recurrent carcinoma of the cervix, postradiation.
|
pubmed:affiliation |
Ottawa Regional Cancer Centre, Ontario, Canada.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|