Linked Life Data

8204653

Source:http://linkedlifedata.com/resource/pubmed/id/8204653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-7-14
pubmed:abstractText
The effects of the negatively charged phospholipid cardiolipin on the structural properties of egg-yolk phosphatidylcholine (EyPC) liposomal membranes were studied by monitoring the water permeability of the liposomes caused by osmotic shrinkage in hypertonic glucose solution. Incorporation of small amounts of bovine heart cardiolipin (BhCL) into the EyPC membranes caused a significant decrease in their water permeability associated with stabilization of the membrane structure. Much evidence obtained by attenuated total reflection IR spectroscopy suggested that incorporation of BhCL into the EyPC membranes causes a cooperative conformational change in the EyPC polar head groups, but does not alter the fluidity of the bilayer structure in the fluid liquid crystalline state. Incorporation of small amounts of BhCL stabilized the intermolecular hydrogen-bonded network including water molecules of the hydration layers at the bilayer surface that are important for the stable bilayer configuration of the EyPC molecules. The antisymmetric PO2- frequencies of the EyPC membrane with incorporated BhCL suggested that the BhCL content of 50 mol% induced a change in the phase behaviors of mixed BhCL/EyPC membranes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
1192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Significant stabilization of the phosphatidylcholine bilayer structure by incorporation of small amounts of cardiolipin.
pubmed:affiliation
Faculty of Pharmaceutical Sciences, University of Tokushima Shomachi-1, Japan.
pubmed:publicationType
Journal Article