Linked Life Data

8204549

Source:http://linkedlifedata.com/resource/pubmed/id/8204549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-7-12
pubmed:abstractText
To assess the effect of propofol on the canine sphincter of Oddi(SO), sphincter of Oddi manometry (SOM) was performed in fasting dogs which had undergone cholecystectomy and placement of modified Thomas duodenal cannulae. Using two water-perfused, single-lumen manometric catheters, SO and duodenal pressures were measured simultaneously. Baseline SO activity was recorded for at least one complete interdigestive cycle followed by bolus injections of propofol (Diprivan) (N = 31) from 0.1 to 4.0 mg/kg during Phase I of the Migrating Motor Complex (MMC). When propofol was administered in bolus doses < or = 0.4 mg/kg, no change in SO or duodenal motor function was seen. In doses > or = 0.5 mg/kg, SO basal pressure, amplitude, and frequency of contractions increased significantly. Increases in duodenal activity paralleled SO activity. Our results suggest that propofol in low doses may be useful for sedation during Sphincter of Oddi manometry in humans. Further studies of the effect of propofol on the human sphincter of Oddi are warranted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0894-8569
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-304
pubmed:dateRevised
2008-11-20
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The effect of propofol on the canine sphincter of Oddi.
pubmed:affiliation
Department of Medicine, Duke University Medical Center, Durham, N.C.
pubmed:publicationType
Journal Article