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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-7-8
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pubmed:abstractText |
Animal studies as well as clinical studies have suggested that the brain 5-HT system is important for the regulation of voluntary ethanol intake and preference. Previous studies have suggested that 5-HT1A receptor agonists may reduce ethanol preference in rats. In the present study on mice, the 5-HT1A receptor agonists (8-OH-DPAT), ipsapirone, and buspirone all antagonized the locomotor activity (LMA) stimulatory effect of ethanol (2.5 g/kg). The present results provide further support for the notion that the LMA-increasing effect of ethanol may be homologous to its reinforcing properties and that 5-HT1A receptor agonists may counteract these properties as well.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0741-8329
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-61
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8204202-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:8204202-Animals,
pubmed-meshheading:8204202-Buspirone,
pubmed-meshheading:8204202-Ethanol,
pubmed-meshheading:8204202-Male,
pubmed-meshheading:8204202-Mice,
pubmed-meshheading:8204202-Motor Activity,
pubmed-meshheading:8204202-Pyrimidines,
pubmed-meshheading:8204202-Receptors, Serotonin,
pubmed-meshheading:8204202-Serotonin Receptor Agonists
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pubmed:articleTitle |
5-HT1A receptor agonists reduce ethanol-induced locomotor activity in mice.
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pubmed:affiliation |
Department of Pharmacology, University of Göteborg, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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