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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
1994-7-7
|
| pubmed:abstractText |
In cross-sectional studies of asymptomatic diabetic patients, multiple abnormalities in left ventricular (LV) function have been found. Long-term significance of these abnormalities is unknown because follow-up studies have not been previously performed. LV ejection fraction (EF) by radionuclide angiocardiography was examined in middle-aged control subjects (n = 44), in patients with insulin-dependent (IDDM) (n = 32) and non-insulin-dependent (NIDDM) (n = 32) diabetes mellitus at baseline and after 4-year follow-up. At baseline, all study subjects were free from cardiovascular disease. LVEF at rest did not differ between the groups at baseline. The decrease in LVEF at rest during follow-up was 1.1 +/- 1.1% (mean +/- SEM) in control subjects, 3.1 +/- 1.3% (p = NS, compared with control subjects) in patients with IDDM, and 7.2 +/- 1.4% (p < 0.01) in patients with NIDDM. At follow-up examination, abnormally low LVEF at rest (< 50%) was found in 7% of control subjects, 13% of patients with IDDM (p = NS), and in 31% of patients with NIDDM (p < 0.05). Compared with control subjects, the prevalence of an abnormal LVEF response to exercise (an increase by < 5%, or a decrease) was higher in diabetic groups at both examinations. This prevalence increased in control subjects from 10% at baseline to 26% at follow-up examination.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0002-9149
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1202-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8203339-Aged,
pubmed-meshheading:8203339-Blood Glucose,
pubmed-meshheading:8203339-Blood Pressure,
pubmed-meshheading:8203339-Cause of Death,
pubmed-meshheading:8203339-Coronary Disease,
pubmed-meshheading:8203339-Cross-Sectional Studies,
pubmed-meshheading:8203339-Death, Sudden, Cardiac,
pubmed-meshheading:8203339-Diabetes Mellitus, Type 1,
pubmed-meshheading:8203339-Diabetes Mellitus, Type 2,
pubmed-meshheading:8203339-Exercise Test,
pubmed-meshheading:8203339-Female,
pubmed-meshheading:8203339-Follow-Up Studies,
pubmed-meshheading:8203339-Heart Rate,
pubmed-meshheading:8203339-Hemoglobin A, Glycosylated,
pubmed-meshheading:8203339-Humans,
pubmed-meshheading:8203339-Incidence,
pubmed-meshheading:8203339-Male,
pubmed-meshheading:8203339-Middle Aged,
pubmed-meshheading:8203339-Radionuclide Angiography,
pubmed-meshheading:8203339-Systole,
pubmed-meshheading:8203339-Ventricular Function, Left
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Left ventricular systolic function in middle-aged patients with diabetes mellitus.
|
| pubmed:affiliation |
Department of Medicine, Kuopio University Hospital, Finland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|