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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1994-7-6
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pubmed:abstractText |
Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28Ick (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G1 and accumulates in G1- and G0-arrested cells. These results suggest that control of the G1/S transition may be influenced by a family of Cdk inhibitors that include p28Ick and the recently described inhibitors p21Cip1/Waf1/Cap20 and p16Ink4.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1329201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1388288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1396589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1398067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1476805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1711413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-1883620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-2138713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-2683077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8114703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8114738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8114739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8242751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8242752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8248208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8259214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8259215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8259216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8288131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8421781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8500168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8202483-8513492
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5291-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8202483-CDC2-CDC28 Kinases,
pubmed-meshheading:8202483-Cell Cycle,
pubmed-meshheading:8202483-Cyclin-Dependent Kinase 2,
pubmed-meshheading:8202483-Cyclin-Dependent Kinases,
pubmed-meshheading:8202483-Cyclins,
pubmed-meshheading:8202483-HeLa Cells,
pubmed-meshheading:8202483-Humans,
pubmed-meshheading:8202483-Lovastatin,
pubmed-meshheading:8202483-Male,
pubmed-meshheading:8202483-Protein Kinase Inhibitors,
pubmed-meshheading:8202483-Protein Kinases,
pubmed-meshheading:8202483-Protein-Serine-Threonine Kinases
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pubmed:year |
1994
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pubmed:articleTitle |
A cell cycle-regulated inhibitor of cyclin-dependent kinases.
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pubmed:affiliation |
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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