Linked Life Data

8200433

Source:http://linkedlifedata.com/resource/pubmed/id/8200433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-7-7
pubmed:abstractText
Elongation of the neuraxis was analyzed quantitatively with respect to the subpopulation of longitudinally oriented mitoses in the neuroepithelium in homozygous embryos of the loop-tail (Lp) mutant mouse, which is characterized by failure of fusion of the neural folds from the midbrain to the tail, as well as a shortening of the neuraxis. Correlations were made with mitotic cell orientation in the underlying gut and notochord, which are likewise shortened. In the abnormal dysraphic embryos at the 7- to 11-somite stage, the percentage of longitudinally oriented mitotic spindles in the neuroepithelium was significantly less than in normal embryos. In contrast, significant differences were not obtained with respect to the orientation of mitotic spindles in the gut or notochord. At the 15- to 20-somite stage, significant differences in mitotic orientation in the neuroepithelium, gut, or notochord did not occur between dysraphic and normal embryos. The results suggest that during elevation and fusion of the neural folds, a decrease in the percentage of longitudinally arranged spindles in the neuroepithelium of Lp/Lp embryos may contribute to the disturbance in neuraxial elongation and possibly closure failure, but that the shortened gut and notochord that also characterize this mutant may not result from defective orientation of mitotic spindles.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:geneSymbol
Lp
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Analysis of neurulation in a mouse model for neural dysraphism.
pubmed:affiliation
Division of Anatomy, School of Medicine, University of California, San Diego, La Jolla 02093.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.