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pubmed-article:8200039pubmed:abstractTextThe phenotype of bovine milk lymphocytes was investigated and compared to peripheral blood lymphocytes using monoclonal antibodies specific for bovine leukocyte differentiation antigens and flow cytometry. T lymphocytes traffic selectively into bovine milk while B lymphocytes represent a minor population in milk by comparison to peripheral blood. The vast majority of T cells in milk express alpha beta T cell receptors and are predominantly CD8+. T cells in milk express twofold higher levels of CD2 and fivefold lower levels of CD45R, characteristics associated with memory T cells. Grouping of cows by lactational stage and analysis of lymphocyte subpopulation percentages indicated that CD4+ T cells are present in relatively low numbers in milk of cows in the first 50 days of lactation and have a significant tendency to increase in number as lactation progresses.lld:pubmed
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pubmed-article:8200039pubmed:articleTitleBovine milk lymphocytes display the phenotype of memory T cells and are predominantly CD8+.lld:pubmed
pubmed-article:8200039pubmed:affiliationDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California at Davis 95616-8739.lld:pubmed
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