Linked Life Data

8199872

Source:http://linkedlifedata.com/resource/pubmed/id/8199872

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-7-7
pubmed:abstractText
The compounds 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ) are endogenous in humans and rats. Whereas TIQ seems to have neurotoxicity, 1-MeTIQ has been described as having a protective effect. In this paper, we report the concentration of TIQ and 1-MeTIQ in two areas especially influenced by aging and Parkinson's disease, the substantia nigra (SN) and striatum (ST), of the rat at different ages. 1-MeTIQ and TIQ were detected in both structures using gas chromatography-mass spectrometry with the higher content of both being in the SN. During the aging process there is a significant decrease (50%) in 1-MeTIQ levels in the SN, but TIQ levels did not change significantly in either of the studied regions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
638
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
334-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Reduction of 1-methyl 1,2,3,4-tetrahydroisoquinoline level in substantia nigra of the aged rat.
pubmed:affiliation
Departamento de Bioquimica, Bromatologia y Toxicologia, Facultad de Farmacia, Universidad de Sevilla, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't