Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-7-7
pubmed:abstractText
Ninety-one patients with de novo acute myeloid leukemia (AML) in first complete remission (CR) undergoing an HLA-identical sibling BMT and with a minimum follow-up of 12 months were analyzed for disease-related and transplant-related variables predicting survival and relapse. The overall actuarial 5 year survival is 53% and the relapse rate 29%, with a medium follow-up for surviving patients of 1552 days (range 365-4094 days). In univariate analysis the following variables were found to be associated with an increased risk of failure: high-dose cyclosporin (CsA), M4-M6 FAB subtype and a long interval (> or = 180 days) between diagnosis and BMT. Other disease-related variables at presentation were not significant, including WBC count > 50 x 10(9)/l, marrow blasts < 70%, time to enter remission > 40 days and > 2 courses to enter remission. Survival was 58% vs 43% for M1-M3 vs M4-M6 FAB subtypes (p = 0.03) and 71% vs 42% for low-dose vs high-dose CsA (p = 0.01). A multivariate analysis was then run separately on survival, relapse and transplant related mortality (TRM). Survival was negatively influenced by M4-M6 FAB subtypes (p = 0.009), high-dose CsA (p = 0.03) and a long interval between diagnosis and BMT (p = 0.04). Leukemia relapse was higher in patients receiving high-dose CsA (p = 0.003) and in females (p = 0.04). Transplant-related mortality was higher in FAB M4-M6 patients (p = 0.01) and patients grafted late after diagnosis (p = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
247-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8199567-Acute Disease, pubmed-meshheading:8199567-Adolescent, pubmed-meshheading:8199567-Adult, pubmed-meshheading:8199567-Bone Marrow Transplantation, pubmed-meshheading:8199567-Child, pubmed-meshheading:8199567-Child, Preschool, pubmed-meshheading:8199567-Cyclosporine, pubmed-meshheading:8199567-Dose-Response Relationship, Drug, pubmed-meshheading:8199567-Female, pubmed-meshheading:8199567-Graft vs Host Disease, pubmed-meshheading:8199567-Humans, pubmed-meshheading:8199567-Infant, pubmed-meshheading:8199567-Leukemia, Myeloid, pubmed-meshheading:8199567-Male, pubmed-meshheading:8199567-Multivariate Analysis, pubmed-meshheading:8199567-Recurrence, pubmed-meshheading:8199567-Remission Induction, pubmed-meshheading:8199567-Retrospective Studies, pubmed-meshheading:8199567-Survival Rate, pubmed-meshheading:8199567-Time Factors, pubmed-meshheading:8199567-Transplantation, Homologous
pubmed:year
1994
pubmed:articleTitle
Allogeneic bone marrow transplantation for acute myeloid leukemia in first complete remission: the effect of FAB classification and GVHD prophylaxis.
pubmed:affiliation
Divisione Ematologia 2, Ospedale San Martino, Genova, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't