Linked Life Data

8197579

Source:http://linkedlifedata.com/resource/pubmed/id/8197579

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-6-27
pubmed:abstractText
The electrophysiological characteristics of two subtypes of striatal neurons, identified by their distinct patterns of response to paired impulse stimulation of corticostriatal afferents, were compared using in vivo intracellular recordings in rats. As observed in previous extracellular recording studies, the majority of neurons (73%) were found to be of the Type II class, with the remaining cells exhibiting the Type I response pattern. For all cells, cortical stimulation elicited 5-30 mV EPSPs at latencies ranging from 2.0-5.3 msec. Increasing the stimulating current intensity caused a progressive increase in the amplitude of the evoked EPSPs without altering their latencies, suggesting that the EPSPs are monosynaptically mediated. Both the average amplitude and duration of the evoked EPSPs at spike threshold in Type I neurons (9.8 +/- 1.7 mV, 11.8 +/- 2.8 msec; mean +/- SEM) were significantly smaller than those of Type II cells (20.3 +/- 1.4 mV, 22.7 +/- 2.1 msec). Although the average latency to the onset of the EPSP was similar for both cell classes (Type I cells: 2.3 +/- 0.3 msec; Type II cells: 2.2 +/- 0.2 msec), the EPSPs in Type I cells reached peak amplitude and the spikes were triggered at significantly longer latencies than in the Type II cells (peak I: 11.2 +/- 2.5 msec vs. II: 7.6 +/- 0.7 msec; spike I: 8.0 +/- 1.2 msec vs. II: 5.7 +/- 0.4 msec). Striatal neurons had a comparatively hyperpolarized resting membrane potential (-70.2 +/- 2.1 mV) and had an average input resistance of 35.4 +/- 7.6 M omega. Overall, striatal neurons exhibited low levels of spontaneous activity (0.6 +/- 0.7 Hz) with 50% of the neurons being quiescent. Type I cells exhibited significantly higher firing rates (3.2 +/- 0.8 Hz) than Type II cells (0.8 +/- 0.3 Hz), although their resting membrane potentials were not significantly different. Spontaneously occurring spikes had an average amplitude of 72.7 +/- 3.4 mV and spike thresholds of -50.1 +/- 1.5 mV. Irregularly occurring depolarizing plateau potentials, which typically gave rise to spike discharge, were frequently observed in both spontaneously firing and quiescent neurons. A small proportion of the cells recorded (3/55) exhibited a Type I response pattern but had unique physiological characteristics that were similar to those described by others as arising from large, aspiny striatal neurons.(ABSTRACT TRUNCATED AT 400 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0887-4476
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Identification and characterization of striatal cell subtypes using in vivo intracellular recording in rats: I. Basic physiology and response to corticostriatal fiber stimulation.
pubmed:affiliation
Department of Behavioral Neuroscience, University of Pittsburgh, Pennsylvania 15260.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't