Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5164
pubmed:dateCreated
1994-6-29
pubmed:abstractText
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1415-21
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:8197455-Amino Acid Sequence, pubmed-meshheading:8197455-Animals, pubmed-meshheading:8197455-Base Sequence, pubmed-meshheading:8197455-Cell Line, pubmed-meshheading:8197455-DNA-Binding Proteins, pubmed-meshheading:8197455-Genes, pubmed-meshheading:8197455-Genetic Complementation Test, pubmed-meshheading:8197455-Humans, pubmed-meshheading:8197455-Interferon-Stimulated Gene Factor 3, pubmed-meshheading:8197455-Interferon-Stimulated Gene Factor 3, gamma Subunit, pubmed-meshheading:8197455-Interferon-alpha, pubmed-meshheading:8197455-Interferon-gamma, pubmed-meshheading:8197455-Molecular Sequence Data, pubmed-meshheading:8197455-Mutation, pubmed-meshheading:8197455-Protein-Tyrosine Kinases, pubmed-meshheading:8197455-Regulatory Sequences, Nucleic Acid, pubmed-meshheading:8197455-Signal Transduction, pubmed-meshheading:8197455-Transcription Factors, pubmed-meshheading:8197455-Transcriptional Activation
pubmed:year
1994
pubmed:articleTitle
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
pubmed:affiliation
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
pubmed:publicationType
Journal Article, Review