Linked Life Data

8197413

Source:http://linkedlifedata.com/resource/pubmed/id/8197413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-30
pubmed:abstractText
Research in genetic epidemiology has provided powerful evidence that genetic factors contribute to the familial transmission of schizophrenia. However, the precise mode of inheritance has not been elucidated, and no disease-susceptibility locus has been identified. Genetically complex illnesses such as schizophrenia can be characterized by multiple intermediate correlated traits or risk factors that likely play important roles in the susceptibility of individuals to developing the illness. Such biobehavioral traits potentially associated with liability to schizophrenia have been carefully studied by experimental psychopathologists and are discussed in this issue. This article discusses how correlated trait data collected from probands and their relatives can complement diagnostic assessments and offer promise for greatly enhancing the informativeness of pedigrees for genetic analysis and for facilitating replication of linkage findings. The results of analyses of simulated and real data discussed here suggest that assessment of biobehavioral traits with the greatest validity and cost-effectiveness should be required in the next generation of linkage and other genetic studies in schizophrenia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0586-7614
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-84
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Indicators of liability to schizophrenia: perspectives from genetic epidemiology.
pubmed:affiliation
Dept. of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't