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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1994-6-27
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pubmed:abstractText |
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. The etiology of the disease is still unknown. Activated T lymphocytes are considered essential in mediating the inflammatory process leading to demyelination in MS. They operate through a complex network of cytokines among which gamma interferon (gamma-IFN) plays a key role. Here we report that exposure to gamma-IFN of T lymphocytes from patients with MS activates, by a protein kinase C-mediated pathway, a previously undescribed gamma-IFN-activated Ca2+ influx, functionally coupled to the gamma-IFN receptor. The influx mainly expressed by CD4+ T lymphocytes, was found in 12 of 15 (80%) patients with clinically active MS and in 14 of 30 (46%) patients with stable MS. The influx was found in only 3 of 24 (12%) control patients and in none of the 15 healthy subjects studied. Our results document the appearance in MS lymphocytes of a gamma-IFN-activated, protein kinase C-dependent, Ca2+ influx that might be due to the expression of a new cation-specific plasmalemma channel. This finding suggests that at least part of gamma-IFN's contribution to the pathogenesis of MS is exerted through a Ca(2+)-dependent regulation of T lymphocyte activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-1296800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-1309781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-1310310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-1331168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-1909108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2164944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2166693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2177344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2453573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2504874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2730577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2808691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-2882294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-3132891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-3134657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-3155735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-318887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-3401689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-3457562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-3838314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-6685237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-8105424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8197142-8500521
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4825-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8197142-Adult,
pubmed-meshheading:8197142-Calcium,
pubmed-meshheading:8197142-Female,
pubmed-meshheading:8197142-Humans,
pubmed-meshheading:8197142-Interferon-gamma,
pubmed-meshheading:8197142-Lymphocyte Activation,
pubmed-meshheading:8197142-Male,
pubmed-meshheading:8197142-Middle Aged,
pubmed-meshheading:8197142-Multiple Sclerosis,
pubmed-meshheading:8197142-Protein Kinase C,
pubmed-meshheading:8197142-T-Lymphocytes
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pubmed:year |
1994
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pubmed:articleTitle |
Gamma interferon activates a previously undescribed Ca2+ influx in T lymphocytes from patients with multiple sclerosis.
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pubmed:affiliation |
Neuroimmunology Unit, University of Milan, San Rafaele Scientific Institute, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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