| pubmed-article:8196636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0025248 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0041219 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0242568 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C1704973 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C0017259 | lld:lifeskim |
| pubmed-article:8196636 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:8196636 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8196636 | pubmed:dateCreated | 1994-6-24 | lld:pubmed |
| pubmed-article:8196636 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8196636 | pubmed:abstractText | We previously described a bloodstream Trypansoma rhodesiense clone, MVAT5-Rx2, whose isolation was based on its cross-reactivity with a monoclonal antibody (MAb) directed against a metacyclic variant surface glycoprotein (VSG). When the duplicated, expressed VSG gene in MVAT5-Rx2 was compared with its donor (basic copy) gene, 11 nucleotide differences were found in the respective 1.5-kb coding regions (Y. Lu, T. Hall, L. S. Gay, and J. E. Donelson, Cell 72:397-406, 1993). Here we describe a characterization of two additional bloodstream trypanosome clones, MVAT5-Rx1 and MVAT5-Rx3, whose VSGs are expressed from duplicated copies of the same donor VSG gene. The three trypanosome clones each react with the MVAT5-specific MAb, but they have different cross-reactivities with a panel of other MAbs, suggesting that their surface epitopes are similar but nonidentical. Each of the three gene duplication events occurs at a different 5' crossover site within a 76-bp repeat and is associated with a different set of point mutations. The 35, 11, and 28 point mutations in the duplicated VSG coding regions of Rx1, Rx2, and Rx3, respectively, exhibit a strand bias. In the sense strand, of the 74 total mutations generated in the three duplications, 54% are A-to-G or G-to-A (A:G) transitions and 7% are C:T transitions, while 26% are C:A transversions and 13% are C:G transversions. No T:G or T:A transversions occurred. Possible models for the generation of these point mutations are discussed. | lld:pubmed |
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| pubmed-article:8196636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8196636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8196636 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8196636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8196636 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8196636 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8196636 | pubmed:author | pubmed-author:DonelsonJ EJE | lld:pubmed |
| pubmed-article:8196636 | pubmed:author | pubmed-author:HallTT | lld:pubmed |
| pubmed-article:8196636 | pubmed:author | pubmed-author:LoSS | lld:pubmed |
| pubmed-article:8196636 | pubmed:author | pubmed-author:ReddyL VLV | lld:pubmed |
| pubmed-article:8196636 | pubmed:author | pubmed-author:AlarconC MCM | lld:pubmed |
| pubmed-article:8196636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8196636 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:8196636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8196636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8196636 | pubmed:pagination | 3971-80 | lld:pubmed |
| pubmed-article:8196636 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8196636 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8196636 | pubmed:articleTitle | A strand bias occurs in point mutations associated with variant surface glycoprotein gene conversion in Trypanosoma rhodesiense. | lld:pubmed |
| pubmed-article:8196636 | pubmed:affiliation | Genetics Ph.D. Program, University of Iowa, Iowa City 52242. | lld:pubmed |
| pubmed-article:8196636 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8196636 | pubmed:publicationType | Comparative Study | lld:pubmed |
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