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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-6-28
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pubmed:abstractText |
To study the reduction of RB90740 (1), a fused pyrazine mono-N-oxide that has an oxic:hypoxic cytotoxicity ratio of > 10 in a range of murine and human tumor cells in vitro.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0360-3016
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
333-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8195029-Animals,
pubmed-meshheading:8195029-Antineoplastic Agents,
pubmed-meshheading:8195029-Cell Hypoxia,
pubmed-meshheading:8195029-Humans,
pubmed-meshheading:8195029-Hydrogen-Ion Concentration,
pubmed-meshheading:8195029-Mice,
pubmed-meshheading:8195029-Oxidation-Reduction,
pubmed-meshheading:8195029-Photochemistry,
pubmed-meshheading:8195029-Pyrazines,
pubmed-meshheading:8195029-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity.
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pubmed:affiliation |
MRC Radiobiology Unit, Chilton, Didcot, Oxon, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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