Linked Life Data

8194390

Source:http://linkedlifedata.com/resource/pubmed/id/8194390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-6-27
pubmed:abstractText
Anatomical and biochemical changes in cerebellum after the onset of pcd gene defects have revealed in addition to Purkinje cell degeneration, the occurrence of secondary degenerative events in granule neurons, neurons of the inferior olivary complex and deep cerebellar nuclei. Transplantation in young mutant animals thereby presents a prospect that not only the missing Purkinje cells may be replaced but the subsequent transneuronal losses may be minimized. The present study has evaluated the outcome of implanting embryonic cerebellar cell suspensions into pcd mutants at the age of 45 day-old, a stage marked by the end of Purkinje cell degeneration. Immunocytochemistry (ICC) was used to monitor the extent of gliosis in host cerebellum and to trace the development of embryonic Purkinje cells grafted. The results suggest that the donor cells have no apparent difficulty in survival during reactive gliosis. Migration of these neuroblasts from the grafted zone into adjacent host molecular layer and significant expression of calcium binding protein (CaBP) by grafted Purkinje cells were noted within 9 days after transplantation. Dendritic patterns of grafted Purkinje cells are well-developed by day 17 post transplantation up to 3 months. In addition, synaptic contacts between host fiber endings and the CaBP-positive dendritic spines are present in the molecular layer of folia containing the graft, suggesting synaptic integration between graft and host.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-4920
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-9
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Embryonic cerebellar graft development during acute phase of gliosis in the cerebellum of pcd mutant mice.
pubmed:affiliation
Institute of Neuroscience, National Yang-Ming Medical College, Taipei, Taiwan, R.O.C.
pubmed:publicationType
Journal Article