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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-6-30
|
| pubmed:abstractText |
We have studied the effects of both hypertension and streptozotocin-induced diabetes mellitus on alpha 1-adrenoceptor mediated vasoconstriction, endothelium-dependent and endothelium-independent vasodilation. The experiments were performed in perfused mesenteric vascular bed preparations taken from age-matched SHR, WKY, diabetic SHR and diabetic WKY. For the alpha 1-adrenoceptor agonist methoxamine, the mesenteric preparations from SHR and diabetic SHR yielded significantly (p < 0.05) stronger maximal responses than preparations taken from WKY and diabetic WKY, respectively. The diabetic state significantly (p < 0.05) decreased the responsiveness to methoxamine in arteries from SHR and WKY. Hypertension does not significantly change the concentration response-curves for (acetyl-beta) methacholine, histamine, adenosine diphosphate and sodium-nitroprusside. However, the sensitivity to endothelium-dependent vasodilation decreased in preparations from diabetic animals (< 0.05). It is concluded that mesenteric resistance arteries from SHR and diabetic SHR are more reactive to alpha 1-adrenoceptor stimulation, whereas diabetes reduces the responsiveness to methoxamine in WKY and SHR. Hypertension does not affect the endothelium-dependent relaxation in mesenteric arteries. However, diabetes decreases the sensitivity to endothelium-dependent relaxation without altering the sensitivity to sodium-nitroprusside. These findings are indicative of a diabetes-induced endothelial dysfunction in mesenteric resistance arteries. In preparations from diabetic hypertensive rats the reduced response to methoxamine and the endothelial dysfunction seem to run parallel.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0803-7051
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
69-76
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8193736-Animals,
pubmed-meshheading:8193736-Blood Pressure,
pubmed-meshheading:8193736-Diabetes Mellitus, Experimental,
pubmed-meshheading:8193736-Endothelium, Vascular,
pubmed-meshheading:8193736-Hypertension,
pubmed-meshheading:8193736-Male,
pubmed-meshheading:8193736-Mesenteric Arteries,
pubmed-meshheading:8193736-Rats,
pubmed-meshheading:8193736-Rats, Inbred SHR,
pubmed-meshheading:8193736-Rats, Inbred WKY,
pubmed-meshheading:8193736-Vascular Resistance,
pubmed-meshheading:8193736-Vasodilation
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
The effects of hypertension and diabetes mellitus on the vascular reactivity of resistance arteries.
|
| pubmed:affiliation |
Department of Pharmacotherapy, University of Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|